This study investigates the effects of hydrogen sulfide (H2S) molecules on the Nrf2 (nuclear factor E2-related factor 2)/HO-1 (heme oxygenase-1) pathway in a mouse model of Parkinson's disease (PD), aiming to elucidate the neuroprotective mechanism of hydrogen sulfide therapy for PD. Real-time fluorescence quantitative PCR was employed to measure the expression levels of glutathione peroxidase (GSH-Px) mRNA, superoxide dismutase (SOD), and Nrf2 in the striatum of the mice. Additionally, Western blot analysis was conducted to assess the protein expression levels of TH and the Nrf2/HO-1 pathway in the striatal tissue. The results indicated that the expression levels of CAT, GSH-Px mRNA, SOD, and Nrf2 showed significant differences between the experimental group and the control group, with notable increases in TH and Nrf2/HO-1 expression (P<0.05). In conclusion, hydrogen sulfide can upregulate the expression levels of Nrf2/HO-1 in the cerebral striatum of PD mice, contributing to its therapeutic effects.

Objective To investigate the effects of wogonin on the proliferation and migration of nasopharyngeal carcinoma cells C666-1 and HK-1. Methods The inhibitory effect of wogonin on nasopharyngeal carcinoma cells C666-1 and HK-1 was determined by CCK8 assay, and IC50 was calculated. The effects of wogonin on the proliferation and independent viability of nasopharyngeal carcinoma cell C666-1 were investigated by plate colony formation test. The effects of wogonin on the migration ability of nasopharyngeal carcinoma cells were studied by scratch test and Transwell migration test. Results The results of CCK8 experiment showed that wogonin significantly inhibited the activity of C666-1 and HK-1 cells, and the inhibitory effect increased with the increase of drug concentration. Under the same drug concentration, the inhibitory effect for 48 h was higher than that for 24 h, and the inhibitory effect was dose-time dependent. The IC50 values of wogonin treated C666-1 cells were 37.15 μmol/L for 24 h and 20.75 μmol/L for 48 h. The IC50 values of HK-1 cells treated with wogonin were 29.09 μmol/L for 24 h and 20.46 μmol/L for 48 h. The results of plate colony experiment showed that after the intervention of wogonin, the number of visible colonies of nasopharyngeal carcinoma cells C666-1 was less and the volume was smaller. Scratch test and Transwell migration test showed that the migration ability of C666-1 and HK-1 cells was significantly inhibited, and the higher the drug concentration, the stronger the inhibition effect. Conclusion Wogonin can inhibit the activity, proliferation and migration of nasopharyngeal carcinoma cells.

The purpose of this study is to investigate and analyze the current situation of college students' self-efficacy in entrepreneurship, and propose improvement and enhancement strategies. The research scale is the Entrepreneurial Self Efficacy Scale. The research method involves conducting a survey on 160 participants, all of whom are students from Hebei Normal University, Hebei University of Economics and Trade, and Shijiazhuang College. SPSS 22.0 is used to conduct independent sample t-tests and ANOVA one-way analysis of variance on the data. And there is also an entrepreneurship interview in this study, involving four graduates of college entrepreneurs. The research conclusion is as follows:1, with a mean of 5.01, the score of entrepreneurial self-efficacy among college students in Shijiazhuang is at a moderate level. 2, There are significant differences in scores among college students at four different levels of total annual household income. 3, There is a significant difference in scores between college students with and without entrepreneurial experience. 4, Whether or not one works as a student cadre during their school years has no impact on their scores.