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Volume 2, 2024 - Issue 1

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Vol. 2 (2024)
Vol. 1 (2023)
Journal Article An open access journal
Open Access Journal Article

Study on the Neuroprotective Mechanism of Hydrogen Sulfide in Regulating the Nrf2/HO-1 Signaling Pathway in Mice with Parkinson's Disease

by Jia Xu 1  and  Yuqian Li 2
1
Beijing Fengtai Youanmen Hospital
2
Beijing No.5 High School
*
Author to whom correspondence should be addressed.
SIA  2024 2(1):22; https://doi.org/doi.org/10.12410/sia0201006
Received: 1 October 2024 / Accepted: 31 October 2024 / Published Online: 5 November 2024
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Abstract

This study investigates the effects of hydrogen sulfide (H2S) molecules on the Nrf2 (nuclear factor E2-related factor 2)/HO-1 (heme oxygenase-1) pathway in a mouse model of Parkinson's disease (PD), aiming to elucidate the neuroprotective mechanism of hydrogen sulfide therapy for PD. Real-time fluorescence quantitative PCR was employed to measure the expression levels of glutathione peroxidase (GSH-Px) mRNA, superoxide dismutase (SOD), and Nrf2 in the striatum of the mice. Additionally, Western blot analysis was conducted to assess the protein expression levels of TH and the Nrf2/HO-1 pathway in the striatal tissue. The results indicated that the expression levels of CAT, GSH-Px mRNA, SOD, and Nrf2 showed significant differences between the experimental group and the control group, with notable increases in TH and Nrf2/HO-1 expression (P<0.05). In conclusion, hydrogen sulfide can upregulate the expression levels of Nrf2/HO-1 in the cerebral striatum of PD mice, contributing to its therapeutic effects.

Keywords: hydrogen sulfide; Parkinson's disease; Oxidative stress; Nrf2/HO-1;
Copyright: © 2024 by Xu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Xu, J.; Li, Y. Study on the Neuroprotective Mechanism of Hydrogen Sulfide in Regulating the Nrf2/HO-1 Signaling Pathway in Mice with Parkinson's Disease. Scientific Innovation in Asia, 2024, 2, 22. https://doi.org/doi.org/10.12410/sia0201006
AMA Style
Xu J, Li Y. Study on the Neuroprotective Mechanism of Hydrogen Sulfide in Regulating the Nrf2/HO-1 Signaling Pathway in Mice with Parkinson's Disease. Scientific Innovation in Asia; 2024, 2(1):22. https://doi.org/doi.org/10.12410/sia0201006
Chicago/Turabian Style
Xu, Jia; Li, Yuqian 2024. "Study on the Neuroprotective Mechanism of Hydrogen Sulfide in Regulating the Nrf2/HO-1 Signaling Pathway in Mice with Parkinson's Disease" Scientific Innovation in Asia 2, no.1:22. https://doi.org/doi.org/10.12410/sia0201006

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