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Scientific Innovation in Asia

Volume 3, 2025 - Issue 2

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Vol. 3 (2025)
Vol. 2 (2024)
Vol. 1 (2023)
Journal Article An open access journal
Open Access Journal Article

Immune milk containing IgG, IgA and lactoferrin (IF) enhanced children's growth, immune capability and disease resistance, a prospective and observational research

by Fang Liu 1 ,  Yi Feng 2 ,  Wenyi Lu 2 ,  Zhichao Fu 2 ,  Yiming Hong 3 ,  Xiaoyu Zhang 4  and  Junyan Fei 5
1
Department of Children's Health Prevention, Guiayi Street Community Health Service Center, Zhenhai District, Ningbo City, Zhejiang Province, China
2
Department of Clinical Nutrition, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
3
Shanghai Yunguan Hospital Management Co., Ltd, China
4
Department of General Practice, Guiayi Street Community Health Service Center, Zhenhai District, Ningbo City, Zhejiang Province, China
*
Author to whom correspondence should be addressed.
SIA  2025 3(2):50; https://doi.org/10.12410/sia0302008
Received: 1 June 2025 / Accepted: 10 June 2025 / Published Online: 13 June 2025
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Abstract

Immune milk containing immunoglobulin A (IgA), immunoglobulin G (IgG), and lactoferrin (IF), as a nutritional supplement that can be added to foods, not only provides essential iron and amino acids but also has the potential to improve immune function and contribute to disease prevention. Methods: Between April 2023 and July 2023, a total of 279 randomly selected kindergarten children in Zhenhai District were included in the study and divided into three groups. These children consumed immune skim milk powder for 3 months. Children’s height, weight, BMI, and disease resistance capability were recorded. Results: The mean heights/weights for Groups 1-3 before intervention are 112.11±0.65/19.02±0.35, 118.84±0.53/21.97±0.44, 104.36±0.54/16.55±0.34, with height/weight increasing as:  1.70±0.05/0.36±0.14, 1.49±0.06/0.71±0.08, 1.52±0.10/0.50±0.08 at the end of the research. Statistical differences in the three groups between three-month post-intervention and pre-intervention were all significant (P<0.01), there were also significant differences were also observed in male and female children. The heights and weights of children are above the standard growth development levels. The health status of the 301 children, including 60.13% upper respiratory tract infections, 4.65% diarrhea, and 3.65% hand-foot-mouth disease, was lower than those reported in the literature. Conclusion: Immune milk containing IgG, IgA, and lactoferrin might enhance children’s immune capability and disease resistance. IgA, IgG, and LF have the potential to be used in both dietary supplements and medicines to improve the health of both humans and animals.

Keywords: immune milk; immunoglobulin A; immunoglobulin G; lactoferrin; immune capability;
Copyright: © 2025 by Liu, Feng, Lu, Fu, Hong, Zhang and Fei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Liu, F.; Feng, Y.; Lu, W.; Fu, Z.; Hong, Y.; Zhang, X.; Fei, J. Immune milk containing IgG, IgA and lactoferrin (IF) enhanced children's growth, immune capability and disease resistance, a prospective and observational research. Scientific Innovation in Asia, 2025, 3, 50. doi:10.12410/sia0302008
AMA Style
Liu F, Feng Y, Lu W et al.. Immune milk containing IgG, IgA and lactoferrin (IF) enhanced children's growth, immune capability and disease resistance, a prospective and observational research. Scientific Innovation in Asia; 2025, 3(2):50. doi:10.12410/sia0302008
Chicago/Turabian Style
Liu, Fang; Feng, Yi; Lu, Wenyi; Fu, Zhichao; Hong, Yiming; Zhang, Xiaoyu; Fei, Junyan 2025. "Immune milk containing IgG, IgA and lactoferrin (IF) enhanced children's growth, immune capability and disease resistance, a prospective and observational research" Scientific Innovation in Asia 3, no.2:50. doi:10.12410/sia0302008

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